Aluminum bromide → HCID 10309663, compound

HRID 2416214Notes

Reaction equation

HRID 2416214 reaction equation
C[O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[C:8]([C:14]3[N:15]=[C:16]([CH2:19][S:20]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)(=[O:22])=[O:21])[S:17][CH:18]=3)[C:9](=[O:13])[NH:10]2)=[CH:5][CH:4]=1.[Al](Br)(Br)Br>CCS>[OH:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[C:8]([C:14]3[N:15]=[C:16]([CH2:19][S:20]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)(=[O:22])=[O:21])[S:17][CH:18]=3)[C:9](=[O:13])[NH:10]2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 24409Aluminum bromideHCID 10309883HCID 10309883, compound

Product 1

HCID 10309663HCID 10309663, compound

Reagents, catalysts & solvents 1

HCID 6343EthanethiolSolvent

Procedure

To a stirred suspension of 7-(methoxy)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1h)-quinolinone (Example 8735) (0.1 g, 0.24 mmole) in EtSH (1 mL) was added AlBr3. Stirring was continued in 14 h. The mixture was poured onto ice water and the solid was filtered. The solid was purified by RP-HPLC to give a tan solid. MS (m/z): 399.50 (m+1).

Workup

  1. additionThe mixture was poured onto ice water
  2. filtrationthe solid was filtered
  3. customThe solid was purified by RP-HPLC
  4. customto give a tan solid

Sources & evidence

ORD record
ord-b666e8c8d6e547aaab1759ae7610a362
Source dataset
uspto-grants-2004_11
Patent number
US06822097B1

Reaction notes

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