HCID 22638572, compound → HCID 10151373, compound

HRID 2416215Notes

Reaction equation

HRID 2416215 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[C:8]([C:14]3N=C(CSC4C=CC=CC=4)S[CH:18]=3)[C:9](=[O:13])[NH:10]2)=[CH:5][CH:4]=1.[NH2:27][C:28](=[S:41])[C:29]([CH3:40])([CH3:39])[S:30]([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)(=[O:32])=[O:31]>CO>[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[C:8]([C:14]3[N:27]=[C:28]([C:29]([CH3:39])([S:30]([C:33]4[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=4)(=[O:32])=[O:31])[CH3:40])[S:41][CH:18]=3)[C:9](=[O:13])[NH:10]2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 22638572HCID 22638572, compoundHCID 22638635HCID 22638635, compound

Product 1

HCID 10151373HCID 10151373, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
120 °C

Procedure

This compound was prepared according to the procedure described for Example 8836(c) by employing 3-(2-bromo-acetyl)-7-methoxy-1H-quinolin-2-one (Example 8741, 250 mg, 0.84 mmol) and 2-amino-1,1-dimethyl-1-(phenylsulfonyl)ethane-2-thione (Step b, 1.7 mL, 1.0 mmol) in 3.5 mL of anhydrous MeOH was heated at 120° C. for 3×5 min by microwave synthesizer. The reaction mixture was cooled to RT. The precipitates were collected by filtration and washed with MeOH and CH2Cl2 to provide the title compound as a white solid. MS m/z: 441 (M+1).

Workup

  1. customThis compound was prepared
  2. temperatureThe reaction mixture was cooled to RT
  3. filtrationThe precipitates were collected by filtration
  4. washwashed with MeOH and CH2Cl2

Sources & evidence

ORD record
ord-0fb304276301458eabbdb4bb53227deb
Source dataset
uspto-grants-2004_11
Patent number
US06822097B1

Reaction notes

Loading…