Methylthiourea → HCID 86610497, compound

HRID 2416220Notes

Reaction equation

HRID 2416220 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:14]=[C:13]2[C:8]([CH:9]=[C:10]([C:16](=O)[CH2:17]Br)[C:11](=[O:15])[NH:12]2)=[CH:7][CH:6]=1)=[O:4].[CH3:20][NH:21][C:22]([NH2:24])=[S:23]>CO>[CH3:1][O:2][C:3]([C:5]1[CH:14]=[C:13]2[C:8]([CH:9]=[C:10]([C:16]3[N:24]=[C:22]([NH:21][CH3:20])[S:23][CH:17]=3)[C:11](=[O:15])[NH:12]2)=[CH:7][CH:6]=1)=[O:4]

Participants

4

Reactant 2

HCID 2723704MethylthioureaHCID 86610498HCID 86610498, compound

Product 1

HCID 86610497HCID 86610497, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound was made analogous to Example 8733, step G. 3-(2-Bromo-acetyl)-2-oxo-1,2-dihydro-quinoline-7-carboxylic acid methyl ester (497 mg, 1.5 mmol) and 1-methyl-2-thiourea (130 mg, 1.4 mmol) in MeOH were heated to 150° C. for 400 seconds in the microwave. MS m/z: 316 (M+1), 314 (M−1).

Sources & evidence

ORD record
ord-5d3f64efa5ee4bbebf10a95a908ae693
Source dataset
uspto-grants-2004_11
Patent number
US06822097B1

Reaction notes

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