HCID 88042769, compound → HCID 88042754, compound

Participants

Reaction Steps

Racemic [trans-2-[5-trifluoromethyl-1-(p-toluenesulfonyl)indol-3-yl]-cyclo-propane-carboxaldehyde (4.13 g, 95%) was prepared from racemic [trans-2-[5-trifluoromethyl-1-(p-toluenesulfonyl)indol-3-yl]cycloprop-1-yl]-N-methoxy-N-methyl-carboxamide in a similar manner to [trans-2-[5-cyano-1-(p-toluenesulfonyl)indol-3-yl]cyclopropane-carboxaldehyde in Example 1. 1H NMR (400 MHz, DMSO-d6) 9.06 (1H, d, J=5.7 Hz), 8.11 (2H, d, J=8.9 Hz), 7.89 (3H, m), 7.69 (1H, d, J=8.8 Hz), 7.40 (2H, d, J=8.0 Hz), 2.86 (1H, m), 2.32 (3H, s), 2.12 (1H, m), 1.71 (2H, m); MS m/e 406 (M−H)−. Anal calcd. for C20H16F3NO3S: C, 58.96; H, 3.95; N, 3.43. Found: C, 58.95; H, 3.96; N, 3.28

Provenance & Evidence