反应详情

Tetrakis-triphenylphosphine-palladium (555 mg; 0.48 mmol) is suspended in dimethoxyethane (7 ml) while gassing with argon, and 5-(3,5-diethoxy-4-iodo-benzyl)-pyrimidine-2,4-diamine (example 1) (4.14 g; 10 mmol) in dimethoxyethane (60 ml) is added. After stirring for 15 minutes at room temperature, 3-amino-phenylboron acid monnohydrate (2.37 g; 15 mmol) in ethanol (17 ml) is added, the mixture is stirred at room temperature for a further 10 minutes, aqueous 2 M sodium carbonate solution (44 ml) is added and the mixture is then boiled under reflux for 4 hours. The reaction mixture is concentrated and the residue is stirred with water and filtered off with suction. The filter cake is stirred with MeOH (230 ml) and filtered off with suction. The filtrate is concentrated and the residue is chromatographed over silica gel (225 g) with methylene chloride/methanol/ammonia (19/1/0.05, later 90/10/1). The pure fractions are combined and concentrated and the residue is dried under a high vacuum.

1. additionis added
2. stirringthe mixture is stirred at room temperature for a further 10 minutes
3. temperatureunder reflux for 4 hours
4. concentrationThe reaction mixture is concentrated
5. stirringthe residue is stirred with water
6. filtrationfiltered off with suction
7. stirringThe filter cake is stirred with MeOH (230 ml)
8. filtrationfiltered off with suction
9. concentrationThe filtrate is concentrated
10. customthe residue is chromatographed over silica gel (225 g) with methylene chloride/methanol/ammonia (19/1/0.05, later 90/10/1)
11. concentrationconcentrated
12. customthe residue is dried under a high vacuum