4-(thiophen-2-ylmethyl)morpholine → HCID 86759558, compound

HRID 2416300Notes

Reaction equation

HRID 2416300 reaction equation
O[CH2:2][C:3]1[S:7][C:6]([B:8])=[CH:5][CH:4]=1.S1C=CC=C1C[N:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1>>[N:15]1([CH2:2][C:3]2[S:7][C:6]([B:8])=[CH:5][CH:4]=2)[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 2408434-(thiophen-2-ylmethyl)morpholineHCID 86759559HCID 86759559, compound

Product 1

HCID 86759558HCID 86759558, compound

Procedure

(5-Morpholin-4-ylmethyl-thiophen-2-yl)-boron acid is prepared analogously to (5-hydroxymethyl-thiophen-2-yl)-boron acid (described in example (2ab)) starting from 4-thiophen-2-ylmethyl-morpholine (1.83 g; 10 mmol).

Sources & evidence

ORD record
ord-ac6f5e35519445178b7d4f779231f066
Source dataset
uspto-grants-2004_11
Patent number
US06821980B1

Reaction notes

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