1-Bromopropane → HCID 22636900, compound

HRID 2416317Notes

Reaction equation

[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9][C:10]2[CH:11]=[C:12]([OH:27])[C:13]([C:19]3[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=3)=[C:14]([O:16][CH2:17][CH3:18])[CH:15]=2)=[CH:4][N:3]=1.Br[CH2:29][CH2:30][CH3:31]>>[CH2:17]([O:16][C:14]1[C:13]([C:19]2[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=2)=[C:12]([O:27][CH2:29][CH2:30][CH3:31])[CH:11]=[C:10]([CH2:9][C:5]2[C:6]([NH2:8])=[N:7][C:2]([NH2:1])=[N:3][CH:4]=2)[CH:15]=1)[CH3:18]

Participants

Reactant 2

HCID 78401-Bromopropane

HCID 22636980HCID 22636980, compound

Product 1

HCID 22636900HCID 22636900, compound

Procedure

Starting from 4-(2,4-diamino-pyrimidin-5-ylmethyl)-6-ethoxy-4′-methoxy-biphenyl-2-ol (200 mg; 0.545 mmol) and 1-bromopropane (0.060 ml; 0.654 mmol), 121 mg (454%) 5-(6-ethoxy-4′-methoxy-2-propory-biphenyl-4-ylmethyl)-pyrimidine-2,4-diamine are obtained as a colourless powder.

Workup

customare obtained as a colourless powder

Sources & evidence

ORD record: ord-4ff98ff76d5c495ba7728169be82aec6
Source dataset: uspto-grants-2004_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06821980B1

Reaction notes

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