HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoro-4-methoxybenzene-1-sulfonyl chloride → 3-Fluoro-4-methoxy-benzenesulphonic acid 3'-amino-4-(2,4-diamino-pyrimidin-5-ylmethyl)-6-ethoxy-biphenyl-2-yl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoro-4-methoxybenzene-1-sulfonyl chloride | HCID 2774540 | — |
| Reactant | 3'-Amino-4-(2,4-diamino-pyrimidin-5-ylmethyl)-6-ethoxy-biphenyl-2-ol | HCID 22636979 | — |
| Product | 3-Fluoro-4-methoxy-benzenesulphonic acid 3'-amino-4-(2,4-diamino-pyrimidin-5-ylmethyl)-6-ethoxy-biphenyl-2-yl ester | HCID 86759562 | 76.1% |
Reaction Steps
Starting from 3′-amino-4-(2,4-diamino-pyrimidin-5-ylmethyl)-6-ethoxy-biphenyl-2-ol (100 mg; 0.28 mmol) and 3-fluoro-4-methoxy-benzenesulphonyl chloride (115 mg; 0.51 mmol), 115 mg of the title compound are obtained as a pale yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06821980B1 |
| Source dataset | uspto-grants-2004_11 |
| ORD ID | ord-1c6509a6b51844f9822a73d43310d88e |
| Source note | uspto-grants-2004_11 |