HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Thiophenesulfonyl chloride → Thiophene-2-sulphonic acid 3'-amino-4-(2,4-diamino-pyrimidin-5-ylmethyl)-6-ethoxy-biphenyl-2-yl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Thiophenesulfonyl chloride | HCID 85518 | — |
| Reactant | 3'-Amino-4-(2,4-diamino-pyrimidin-5-ylmethyl)-6-ethoxy-biphenyl-2-ol | HCID 22636979 | — |
| Product | Thiophene-2-sulphonic acid 3'-amino-4-(2,4-diamino-pyrimidin-5-ylmethyl)-6-ethoxy-biphenyl-2-yl ester | HCID 17937347 | 51.7% |
Reaction Steps
Starting from 3′-amino-4-(2,4-diamino-pyrimidin-5-ylmethyl)-6-ethoxy-biphenyl-2-ol (100 mg; 0.28 mmol) and 2-thienylsulfonyl chloride (94 mg; 0.51 mmol), 72 mg of the title compound are isolated as a yellow foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06821980B1 |
| Source dataset | uspto-grants-2004_11 |
| ORD ID | ord-50eee2a99e764dd0bf92b04e773155c5 |
| Source note | uspto-grants-2004_11 |