HCID 22636806, compound → HCID 22636862, compound

HRID 2416321Notes

Reaction equation

HRID 2416321 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:21]=[C:22]([O:25][CH2:26][CH3:27])[C:23]=1I)[CH2:12][C:13]1[C:14]([NH2:20])=[N:15][C:16]([NH2:19])=[N:17][CH:18]=1)[C:2]1C=CC=[CH:4][CH:3]=1.[N:28]1([CH2:34][C:35]2[S:39][C:38]([B])=[CH:37][CH:36]=2)[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1>>[CH:2]1([CH2:1][O:8][C:9]2[CH:10]=[C:11]([CH:21]=[C:22]([O:25][CH2:26][CH3:27])[C:23]=2[C:38]2[S:39][C:35]([CH2:34][N:28]3[CH2:33][CH2:32][O:31][CH2:30][CH2:29]3)=[CH:36][CH:37]=2)[CH2:12][C:13]2[C:14]([NH2:20])=[N:15][C:16]([NH2:19])=[N:17][CH:18]=2)[CH2:3][CH2:4]1

Participants

3

Reactant 2

HCID 22636806HCID 22636806, compoundHCID 86759558HCID 86759558, compound

Product 1

HCID 22636862HCID 22636862, compound

Procedure

Prepared analogously to example (2ac) starting from 5-(3-benzyloxy-5-ethoxy-4-iodo-benzyl)-pyrimidine-2,4-diamine (example 6) (1.429 g; 3 mmol) and (5-morpholin-4-ylmethyl-thiophen-2-yl)-boron acid (681 mg; 3 mmol).

Workup

  1. customPrepared analogously to example (2ac)

Sources & evidence

ORD record
ord-a3c3c6a73d6a4941ba19d201042fd63d
Source dataset
uspto-grants-2004_11
Patent number
US06821980B1

Reaction notes

Loading…