HRID2416329

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCOc1cc(Cc2cnc(N)nc2N)cc(OS(=O)(=O)C(C)CC)c1I

HCID17937260

未命名化合物

HCID22636976

未命名化合物

PRODUCTS

生成物

结构：CCOc1cc(Cc2cnc(N)nc2N)cc(OS(=O)(=O)C(C)CC)c1-c1ccc(CN2CCOCC2)c(N)c1

HCID17937331

未命名化合物

收率 57.7%

PROCEDURE

实验过程

Starting from 308 mg (0.84 mmol) N-(5-bromo-2-morpholin-4-ylmethyl-phenyl)-2,2,2-trifluoro-acetamide and 214 mg (0.422 mmol) butane-2-sulphonic acid 5-(2,4-diamino-pyrimidin-5-ylmethyl)-3-ethoxy-2-iodo-phenyl ester, 139 mg of the title compound are obtained as pale brown crystals.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3546528182e14c8f91a61fb598e99169
来源数据集: uspto-grants-2004_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06821980B1
来源说明: uspto-grants-2004_11

反应 SMILES

Br[C:2]1[CH:3]=[CH:4][C:5]([CH2:15][N:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)=[C:6]([NH:8]C(=O)C(F)(F)F)[CH:7]=1.[NH2:22][C:23]1[N:28]=[C:27]([NH2:29])[C:26]([CH2:30][C:31]2[CH:32]=[C:33]([O:46][CH2:47][CH3:48])[C:34](I)=[C:35]([O:37][S:38]([CH:41]([CH2:43][CH3:44])[CH3:42])(=[O:40])=[O:39])[CH:36]=2)=[CH:25][N:24]=1>>[NH2:8][C:6]1[CH:7]=[C:2]([C:34]2[C:33]([O:46][CH2:47][CH3:48])=[CH:32][C:31]([CH2:30][C:26]3[C:27]([NH2:29])=[N:28][C:23]([NH2:22])=[N:24][CH:25]=3)=[CH:36][C:35]=2[O:37][S:38]([CH:41]([CH2:43][CH3:44])[CH3:42])(=[O:39])=[O:40])[CH:3]=[CH:4][C:5]=1[CH2:15][N:16]1[CH2:17][CH2:18][O:19][CH2:20][CH2:21]1