HCID 4253276, compound → 2-Methyl-propane-1-sulphonic acid 4'-amino-4-(2,4-diamino-pyrimidin-5-ylmethyl)-6-ethoxy-3'-fluoro-biphenyl-2-yl ester

HRID 2416331Notes

Reaction equation

HRID 2416331 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([NH:8]C(=O)C(F)(F)F)=[C:4]([F:15])[CH:3]=1.[NH2:16][C:17]1[N:22]=[C:21]([NH2:23])[C:20]([CH2:24][C:25]2[CH:26]=[C:27]([O:40][CH2:41][CH3:42])[C:28](I)=[C:29]([O:31][S:32]([CH2:35][CH:36]([CH3:38])[CH3:37])(=[O:34])=[O:33])[CH:30]=2)=[CH:19][N:18]=1>>[NH2:8][C:5]1[CH:6]=[CH:7][C:2]([C:28]2[C:27]([O:40][CH2:41][CH3:42])=[CH:26][C:25]([CH2:24][C:20]3[C:21]([NH2:23])=[N:22][C:17]([NH2:16])=[N:18][CH:19]=3)=[CH:30][C:29]=2[O:31][S:32]([CH2:35][CH:36]([CH3:37])[CH3:38])(=[O:33])=[O:34])=[CH:3][C:4]=1[F:15]

Participants

3

Reactant 2

HCID 4253276HCID 4253276, compoundHCID 17937271HCID 17937271, compound

Product 1

HCID 179373092-Methyl-propane-1-sulphonic acid 4'-amino-4-(2,4-diamino-pyrimidin-5-ylmethyl)-6-ethoxy-3'-fluoro-biphenyl-2-yl esterYield 79.8%

Procedure

Starting from 241 mg (0.84 mmol) N-(4-bromo-2-fluoro-phenyl)-2,2,2-trifluoro-acetamide and 215 mg (0.42 mmol) 2-methyl-propane-1-sulphonic acid 5-(2,4-diamino-pyrimidin-5-ylmethyl)-3-ethoxy-2-iodo-phenyl ester, 164 mg of the title compound are obtained as a pale brown foam.

Sources & evidence

ORD record
ord-2b5c34f35be745f5baefc02e7469b140
Source dataset
uspto-grants-2004_11
Patent number
US06821980B1

Reaction notes

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