Sodium Carbonate → Tetrahydrofuran-2-yl-methanesulphonic acid 3'-amino-4-(2,4-diamino-pyrimidin-5-ylmethyl)-6-ethoxy-biphenyl-2-yl ester

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Reaction Steps

Starting from tetrahydrofuran-2-yl)-methanesulphonic acid 5-(2,4-diamino-pyrimidin-5-ylmethyl)-3-ethoxy-2-iodo-phenyl ester (220 mg; 0.5 mmol), 3-aminophenyl-boron acid (98 mg; 0.63 mmol), tetrakis-triphenylphosphine-palladium (29 mg; 0.03 mmol) and aqueous 2 M sodium carbonate solution (3.2 ml; 6.4 mmol) in a 4/1 dimethoxyethane/ethanol mixture (10 ml) (52%) tetrahydrofuran-2-yl-methanesulphonic acid 3′-amino-4-(2,4-diamino-pyrimidin-5-ylmethyl)-6-ethoxy-biphenyl-2-yl ester are obtained as a yellow foam.

Provenance & Evidence