2-Bromoethyl methyl ether → HCID 22636781, compound

Participants

Reaction Steps

4′-(2,4-Diamino-pyrimidin-5-ylmethyl)-2′,6′-diethoxy-biphenyl-3-ol (200 mg; 0.526 mmol) is suspended in dimethylformamide (5 ml; dried over a molecular sieve), and potassium tert-butylate (83 mg; 0.736 mmol) is added at room temperature. 2-Bromoethyl methyl ether (0.059 ml; 0.63 mmol) in dimethylformamide (5 ml; dried over a molecular sieve) is added in the course of 35 minutes to the solution formed. After stirring at room temperature for 12 hours, the reaction mixture is concentrated and the residue is stirred successively with water (twice) and diethyl ether, filtered off with suction and dried under a high vacuum.

Provenance & Evidence