Acetic acid 10-acetoxymethyl-anthracen-9-ylmethyl ester → HCID 88053641, compound

Participants

Reaction Steps

Starting from propane-2-sulphonic acid 4-(2,4-diamino-pyrimidin-5-ylmethyl)-6-ethoxy-4′-hydroxy-biphenyl-2-yl ester (example 15c) (137 mg; 0.30 mmol), potassium tert-butylate (42 mg; 0.37 mmol) and acetic anhydiide (0.028 ml; 0.30 mmol) in dimethylformamide (3.5 ml) at 0-5° C. (15 minutes) and then room temperature (3 hours), 39 mg (27%) 4′-(2,4-diamino-pyrimidin-5-ylmethyl)-6′-ethoxy-2′-(propane-2-sulphonyloxy)-biphenyl-4-yl acetate are obtained as a colourless powder.

Provenance & Evidence