Hydrochloric Acid → HCID 60123478, compound

Participants

Reaction Steps

A mixture of (R)-3-(5-acetoxyhexyl)-1,7-dimethylpyrido[2,3-d]pyrimidine-2,4,5(1H,3H,8H)-trione (100 mg, 0.286 mmol), diethyl ether (0.5 ml) and 3 M aqueous hydrochloric acid solution (5 ml) was stirred at room temperature for 18 hours. After treating with saturated aqueous sodium bicarbonate (20 ml), the mixture was extracted with diethyl ether (2×20 ml). The combined extracts were dried over sodium sulfate, and concentrated under vacuum to afford (R)-1,7-dimethyl-3-(5-hydroxyhexyl)pyrido[2,3-d]pyrimidine-2,4,5(1H,3H,8H)-trione (81 mg, 92% yield) a white powder. 1H NMR (300 MHz, CDCl3) δ 1.17 (d, 3H), 1.30-1.52 (m, 3H), 1.54-1.70 (m, 4H), 2.45 (s, 3H), 3.62 (s, 3H), 3.77 (m, 1H), 4.00 (t, 2H), 6.49 (s, 1H), 12.15 (s, 1H).

Provenance & Evidence