Dimethylamine → HCID 69732926, compound

Participants

Reaction Conditions

Reaction Steps

A pressure tube was charged with (R)-3-(5-acetoxyhexyl)-1,7-dimethyl-5-trifluoromethanesulfonyloxypyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione (100 mg, 0.208 mmol) and tetrahydrofuran (1 ml). After cooling to 0° C., dimethylamine gas was introduced until approximately 1 ml had collected. The tube was sealed and heated at 55° C. for 18 hours. After cooling to room temperature, the tube was carefully vented and the dimethylamine was evaporated to provide crude (R)-3-(5-acetoxyhexyl)-1,7-dimethyl-5-(N,N-dimethylamino)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione.

Provenance & Evidence