Benzyl Bromide → HCID 69733083, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (R)-3-(5-acetoxyhexyl)-1,7-dimethylpyrido[2,3-d]pyrimidine-2,4,5(1H,3H,8H)-trione (1.84 g, 5.27 mmol), acetonitrile (20 ml), benzyl bromide (0.95 ml, 7.91 mmol) and potassium carbonate (2.19 g, 15.8 mmol) was stirred at 50° C. for 2 hours. After cooling to room temperature, the mixture was concentrated under reduced pressure. The residue was treated with water (50 ml) and extracted with ethyl acetate (50 ml). The organic extract was concentrated under reduced pressure to afford crude (R)-3-(5-acetoxyhexyl)-8-benzyl-1,7-dimethylpyrido[2,3-d]pyrimidine-2,4,5(1H,3H,8H)-trione.

Provenance & Evidence