Acetylacetone → HCID 69732524, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (R)-3-(5-acetoxyhexyl)-6-amino-1-methyluracil (250 mg, 0.88 mmol), 2,4-pentanedione (2 ml, 19.5 mmol) and xylenes (3 ml) was heated to 145° C. for 18 hours. The mixture was concentrated under reduced pressure followed by coevaporation with toluene (2×5 ml) to remove the remaining 2,4-pentanedione to provide crude (R)-3-(5-acetoxyhexyl)-1,5,7-trimethylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione.

Provenance & Evidence