Benzenebutanol → 4-Phenylbutanal

Participants

Reaction Steps

4-Phenylbutanol (700 mg, 4.66 mmol) was added to a solution of the Dess-Martin reagent (2.40 g, 5.66 mol) in dichloromethane (35 mL). After 30 min at RT, the solution was quenched with 10% aq. Na2S2O3, washed with sat. aq. NaHCO3 and brine, dried (Na2SO4), and concentrated. Purification by chromatography (SiO2, 9:1 hexane/ethyl acetate) yielded the title compound. MS 149 (M+H)+.

Provenance & Evidence