Trimethylsilyl isocyanate → HCID 46851886, compound

HRID 241645Notes

Reaction equation

[NH:1]1[CH2:4][CH:3]([S:5]([C:8]2[CH:28]=[CH:27][C:11]3[N:12]([CH2:20][CH2:21][O:22][C:23]([F:26])([F:25])[F:24])[C:13]([CH2:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[N:14][C:10]=3[CH:9]=2)(=[O:7])=[O:6])[CH2:2]1.C[Si]([N:33]=[C:34]=[O:35])(C)C>>[CH2:15]([C:13]1[N:12]([CH2:20][CH2:21][O:22][C:23]([F:24])([F:26])[F:25])[C:11]2[CH:27]=[CH:28][C:8]([S:5]([CH:3]3[CH2:2][N:1]([C:34]([NH2:33])=[O:35])[CH2:4]3)(=[O:7])=[O:6])=[CH:9][C:10]=2[N:14]=1)[C:16]([CH3:19])([CH3:18])[CH3:17]

Participants

Reactant 2

HCID 70696Trimethylsilyl isocyanate

HCID 58513606HCID 58513606, compound

Product 1

HCID 46851886HCID 46851886, compound

Procedure

The title compound was prepared according to the procedure described in STEP D of Example 6 using 5-(azetidin-3-ylsulfonyl)-2-neopentyl-1-(2-(trifluoromethoxy)ethyl)-1H-benzo[d]imidazole (STEP C of Example 7) and trimethylsilyl isocyanate instead of methanesulfonyl chloride.

Sources & evidence

ORD record: ord-480450919f62422c8c658a5d36e851c7
Source dataset: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08653063B2

Reaction notes

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