tert-butyl 4-(1-(cyclopropylmethyl)-2-neopentyl-1H-benzo[d]imidazol-5-ylsulfonyl)piperidine-1-carboxylate → 1-(cyclopropylmethyl)-2-neopentyl-5-(piperidin-4-ylsulfonyl)-1H-benzo[d]imidazole

HRID 241646Notes

Reaction equation

HRID 241646 reaction equation
[CH:1]1([CH2:4][N:5]2[C:9]3[CH:10]=[CH:11][C:12]([S:14]([CH:17]4[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]4)(=[O:16])=[O:15])=[CH:13][C:8]=3[N:7]=[C:6]2[CH2:30][C:31]([CH3:34])([CH3:33])[CH3:32])[CH2:3][CH2:2]1.C1(CN2C3C=CC(S(CC4CCN(C(OC(C)(C)C)=O)CC4)(=O)=O)=CC=3N=C2CC(C)(C)C)CC1>>[CH:1]1([CH2:4][N:5]2[C:9]3[CH:10]=[CH:11][C:12]([S:14]([CH:17]4[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]4)(=[O:15])=[O:16])=[CH:13][C:8]=3[N:7]=[C:6]2[CH2:30][C:31]([CH3:34])([CH3:33])[CH3:32])[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 58513589tert-butyl 4-(1-(cyclopropylmethyl)-2-neopentyl-1H-benzo[d]imidazol-5-ylsulfonyl)piperidine-1-carboxylateHCID 58513612HCID 58513612, compound

Product 1

HCID 585136051-(cyclopropylmethyl)-2-neopentyl-5-(piperidin-4-ylsulfonyl)-1H-benzo[d]imidazole

Procedure

The title compound was prepared according to the procedure described in STEP D of Example 5 using tert-butyl 4-(1-(cyclopropylmethyl)-2-neopentyl-1H-benzo[d]imidazol-5-ylsulfonyl)piperidine-1-carboxylate (STEP C) and tert-butyl 4-((1-(cyclopropylmethyl)-2-neopentyl-1H-benzo[d]imidazol-5-ylsulfonyl)methyl)piperidine-1-carboxylate.

Sources & evidence

ORD record
ord-12aea4f7533c402a945e4e9bd8746485
Source dataset
uspto-grants-2014_02
Patent number
US08653063B2

Reaction notes

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