4-(1H-Pyrazol-1-yl)benzaldehyde → (2E)-3-[4-(4-Methyl-2-pyrimidinyl)phenyl]-2-propenal

HRID 2416474Notes

Reaction equation

HRID 2416474 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]2[CH:15]=[CH:14][C:11]([CH:12]=O)=[CH:10][CH:9]=2)[N:3]=1.N1(C2C=C[C:24]([CH:25]=[O:26])=CC=2)C=CC=N1>>[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]2[CH:15]=[CH:14][C:11](/[CH:12]=[CH:24]/[CH:25]=[O:26])=[CH:10][CH:9]=2)[N:3]=1

Participants

3

Reactant 2

HCID 27764774-(1H-Pyrazol-1-yl)benzaldehydeHCID 226308614-(4-Methylpyrimidin-2-YL)benzaldehyde

Product 1

HCID 22630808(2E)-3-[4-(4-Methyl-2-pyrimidinyl)phenyl]-2-propenal

Procedure

The title compound was prepared by a procedure analogous to Reference Example 30 by substituting 4-(4-methyl-2-pyrimidinyl)benzaldehyde (prepared as described in Reference Example 14) for the 4-(1H-pyrazol-1-yl)-benzaldehyde of Reference Example 30. MS 225 (M+H)+.

Sources & evidence

ORD record
ord-63930a645eb545568827fc932f5de1ea
Source dataset
uspto-grants-2004_11
Patent number
US06825170B2

Reaction notes

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