4-(1H-Pyrazol-1-yl)benzaldehyde → 3-(Quinolin-7-yl)prop-2-enal

HRID 2416480Notes

Reaction equation

HRID 2416480 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH:11]=O)[CH:9]=2)[CH:4]=[CH:3][CH:2]=1.N1(C2C=C[C:21]([CH:22]=[O:23])=CC=2)C=CC=N1>>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8](/[CH:11]=[CH:21]/[CH:22]=[O:23])[CH:9]=2)[CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 27764774-(1H-Pyrazol-1-yl)benzaldehydeHCID 47122557-Quinolinecarboxaldehyde

Product 1

HCID 226311883-(Quinolin-7-yl)prop-2-enal

Procedure

The title compound was prepared by a procedure analogous to Reference Example 30 by substituting 7-quinolinecarboxaldehyde (prepared as described in J. Med. Chem. 1993, 36, 3308) for the 4-(1H-pyrazol-1-yl)-benzaldehyde of Reference Example 30. MS 184 (M+H)+.

Sources & evidence

ORD record
ord-9d7e9b68e0194e02a410e0ada0d13c30
Source dataset
uspto-grants-2004_11
Patent number
US06825170B2

Reaction notes

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