2-(4-Methylphenyl)-1,3-oxazole → 4-(1,2,4-Oxadiazol-3-yl)benzaldehyde

HRID 2416506Notes

Reaction equation

HRID 2416506 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]=[CH:11][O:10][N:9]=2)=[CH:4][CH:3]=1.CC1C=CC(C2[O:21]C=CN=2)=CC=1>>[O:10]1[CH:11]=[N:12][C:8]([C:5]2[CH:4]=[CH:3][C:2]([CH:1]=[O:21])=[CH:7][CH:6]=2)=[N:9]1

Participants

3

Reactant 2

HCID 123717532-(4-Methylphenyl)-1,3-oxazoleHCID 124131153-(4-Methylphenyl)-1,2,4-oxadiazole

Product 1

HCID 226309454-(1,2,4-Oxadiazol-3-yl)benzaldehyde

Procedure

The title compound is prepared by a procedure analogous to Step B of Reference Example 73 by substituting 3-(4-methylphenyl)-1,2,4-oxadiazole (prepared as described in Bull. Chem. Soc. Jpn. 1978, 51,1484) for the 2-(4-methylphenyl)oxazole of Step B of Reference Example 73. MS 175 (M+H)+.

Sources & evidence

ORD record
ord-b2077322b75c4e50b4dc69c0bb65cd23
Source dataset
uspto-grants-2004_11
Patent number
US06825170B2

Reaction notes

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