HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2416507Generated: November 2, 2026
Sodium Hydroxide → 5-(4-Methylphenyl)-1,2,4-oxadiazole
https://huagongshe.com/reaction/2416507
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | N-dimethylaminomethylene-4-methyl-benzamide | HCID 22630938 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 5-(4-Methylphenyl)-1,2,4-oxadiazole | HCID 22339789 | — |
Reaction Steps
To a solution of 3.54 g (0.0510 mol) of hydroxylamine hydrochloride in a mixture of 10.2 mL (0.0510 mol) of 5 N NaOH, dioxane (50 mL), and 70% aq. acetic acid (100 mL), is added 6.79 g (0.0424) of N-[(dimethylamino)methylene]-4-methylbenzamide (prepared as described in J. Chem. Soc. Perkin. Trans. 1 1989, 589). The mixture is stirred at 90° C. for 1.5 h and the product is isolated from the cooled reaction mixture. MS 161 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06825170B2 |
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| Source dataset | uspto-grants-2004_11 |
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| ORD ID | ord-0b8a2221974b43c1a2e7a644e0119835 |
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| Source note | uspto-grants-2004_11 |
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