4-(1H-Pyrazol-1-yl)benzaldehyde → (2E)-3-[4-(2-pyrimidinyl)-2-thienyl]-2-propenal

HRID 2416524Notes

Reaction equation

HRID 2416524 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[C:7]1[CH:8]=[C:9]([CH:12]=O)[S:10][CH:11]=1.N1(C2C=C[C:22]([CH:23]=[O:24])=CC=2)C=CC=N1>>[N:3]1[CH:4]=[CH:5][CH:6]=[N:1][C:2]=1[C:7]1[CH:8]=[C:9](/[CH:12]=[CH:22]/[CH:23]=[O:24])[S:10][CH:11]=1

Participants

3

Reactant 2

HCID 27764774-(1H-Pyrazol-1-yl)benzaldehydeHCID 226312394-(2-Pyrimidinyl)-2-thiophenecarboxaldehyde

Product 1

HCID 22630871(2E)-3-[4-(2-pyrimidinyl)-2-thienyl]-2-propenal

Procedure

The title compound is prepared by a procedure analogous to Reference Example 30 by substituting 4-(2-pyrimidinyl)-2-thiophenecarboxaldehyde (prepared as described in Reference Example 90) for the 4-(1H-pyrazol-1-yl)-benzaldehyde of Reference Example 30. MS 217 (M+H)+.

Sources & evidence

ORD record
ord-8377b65e37ad4ba3834480f595652419
Source dataset
uspto-grants-2004_11
Patent number
US06825170B2

Reaction notes

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