反应详情

The mixture of 1-(cyclopropylmethyl)-2-(2,2-dimethylpropyl)-5-[(piperidin-4-ylmethane)sulfonyl]-1,3-benzodiazole (STEP D of Example 5, 25 mg, 0.062 mmol), sulfamide (15 mg, 0.16 mmol)and 1,4-dioxane was refluxed for 6 h. The reaction mixture was concentrated in vacuo and extracted with ethyl acetate (20 mL) and water (30 mL). The organic layer was washed with water (20 mL) and brine (15 mL), dried over magnesium sulfate. The crude product (27 mg) was purified by prep LC-MS(“process A”).

1. temperaturewas refluxed for 6 h
2. concentrationThe reaction mixture was concentrated in vacuo
3. extractionextracted with ethyl acetate (20 mL) and water (30 mL)
4. washThe organic layer was washed with water (20 mL) and brine (15 mL)
5. dry with materialdried over magnesium sulfate
6. customThe crude product (27 mg) was purified by prep LC-MS(“process A”)