Trimethylsilyl iodide → HCID 22630912, compound

Participants

Reaction Steps

Iodotrimethylsilane (0.46 mL, 3.30 mmol) was added dropwise to a suspension of the product from step A (175 mg, 0.82 mmol) and solid NaHCO3 (100 mg, 1.18 mmol) in dichloromethane (5 mL) at rt. The reaction mixture was stirred at rt for 18 h, carefully quenched with sat. aq. NaHCO3, extracted with dichloromethane, dried with Na2SO4, and concentrated in vacuo to give 110 mg (68%) of the title compound. The product was >95% pure as judged by its 1H NMR spectrum, and was used immediately in the next step without further purification. MS 199 (M+H)+.

Provenance & Evidence