3-(3-(Pyridin-2-yl)isoxazol-5-yl)prop-2-yn-1-ol → 3-[3-(2-Pyridinyl)-5-isoxazolyl]-2-propynal

HRID 2416555Notes

Reaction equation

HRID 2416555 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:11]=[C:10]([C:12]#[C:13][CH2:14][OH:15])[O:9][N:8]=1.N1C=CC=NC=1C1C=CC(C#CCO)=CC=1>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:11]=[C:10]([C:12]#[C:13][CH:14]=[O:15])[O:9][N:8]=1

Participants

3

Reactant 2

HCID 226308213-(3-(Pyridin-2-yl)isoxazol-5-yl)prop-2-yn-1-olHCID 226311353-[4-(2-Pyrimidinyl)phenyl]-2-propyn-1-ol

Product 1

HCID 226308473-[3-(2-Pyridinyl)-5-isoxazolyl]-2-propynal

Procedure

The title compound is prepared by a procedure analogous to Reference Example 300 by substituting 3-[3-(2-pyridinyl)-5-isoxazolyl]-2-propyn-1-ol (prepared as described in Reference Example 294) for the 3-[4-(2-pyrimidinyl)phenyl]-2-propyn-1-ol of Reference Example 300. MS 199 (M+H)+.

Sources & evidence

ORD record
ord-e280b9ff3881492d956b5c8c28307245
Source dataset
uspto-grants-2004_11
Patent number
US06825170B2

Reaction notes

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