Trimethylsilyl isocyanate → HCID 46852048, compound

HRID 241656Notes

Reaction equation

[NH:1]1[CH2:4][CH:3]([S:5]([C:8]2[CH:31]=[CH:30][C:11]3[N:12]([CH2:20][CH:21]4[CH2:26][CH2:25][N:24]([C:27](=[O:29])[CH3:28])[CH2:23][CH2:22]4)[C:13]([CH2:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[N:14][C:10]=3[CH:9]=2)(=[O:7])=[O:6])[CH2:2]1.C[Si]([N:36]=[C:37]=[O:38])(C)C>>[C:27]([N:24]1[CH2:25][CH2:26][CH:21]([CH2:20][N:12]2[C:11]3[CH:30]=[CH:31][C:8]([S:5]([CH:3]4[CH2:4][N:1]([C:37]([NH2:36])=[O:38])[CH2:2]4)(=[O:7])=[O:6])=[CH:9][C:10]=3[N:14]=[C:13]2[CH2:15][C:16]([CH3:19])([CH3:18])[CH3:17])[CH2:22][CH2:23]1)(=[O:29])[CH3:28]

Participants

Reactant 2

HCID 70696Trimethylsilyl isocyanate

HCID 58513611HCID 58513611, compound

Product 1

HCID 46852048HCID 46852048, compound

Procedure

The title compound was prepared according to the procedure described in STEP D of Example 6 using 1-(4-((5-(azetidin-3-ylsulfonyl)-2-neopentyl-1H-benzo[d]imidazol-1-yl)methyl)piperidin-1-yl)ethanone (STEP D) and trimethylsilyl isocyanate instead of methanesulfonyl chloride.

Sources & evidence

ORD record: ord-61aca2f509a84eb9bf7eab8d892f892a
Source dataset: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08653063B2

Reaction notes

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