Methyl iodide → 5-Methoxyisoquinoline

Participants

Reaction Steps

5.6 g (38.6 mmol) of 5-hydroxyisoquinoline was dissolved in 70 ml of DMF. 2.63 ml (38.6 mmol) of methyl iodide and 7.99 g (57.9 mmol) of potassium carbonate were added to the obtained solution, and they were stirred at room temperature overnight. After the treatment with ethyl acetate as the extracting solvent in an ordinary manner, the crude product was obtained. It was purified by the silica gel column chromatography to obtain the title compound.

Provenance & Evidence