Acetyl chloride → 1-(4-{[1-(cyclopropylmethyl)-2-(2,2-dimethylpropyl)-1H-1,3-benzodiazole-5-sulfonyl]methyl}piperidin-1-yl)ethan-1-one

Participants

Role	Name	HCID	Charge
Reactant	Acetyl chloride	HCID 6367	—
Reactant	Methanesulfonyl chloride	HCID 31297	—
Reactant	HCID 58513582	HCID 58513582	—
Product	1-(4-{[1-(cyclopropylmethyl)-2-(2,2-dimethylpropyl)-1H-1,3-benzodiazole-5-sulfonyl]methyl}piperidin-1-yl)ethan-1-one	HCID 46852213	—

Reaction Steps

The title compound was prepared according to the procedure described in STEP D of Example 6 using 1-(cyclopropylmethyl)-2-(2,2-dimethylpropyl)-5-[(piperidin-4-ylmethane)sulfonyl]-1,3-benzodiazole (STEP D of Example 5) and acetyl chloride instead of 5-(azetidin-3-ylmethylsulfonyl)-1-(cyclopropylmethyl)-2-neopentyl-1H-benzo[d]imidazole and methanesulfonyl chloride.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08653063B2
Source dataset	uspto-grants-2014_02
ORD ID	ord-8a1d2c36e7614a6cbde0eca3fb966849
Source note	uspto-grants-2014_02