Ethyl Acetate → 7-Methoxyisoquinoline

Participants

Reaction Steps

17.8 g (45 mmol) of N-(2,2-dimethoxyethyl)-N-(3-methoxybenzyl)-4-methylbenzenesulfonamide was dissolved in 250 ml of dioxane and 70 ml of 6 N hydrochloric acid. After heating under reflux for 5 hours, the product was treated with ethyl acetate as the extracting solvent in an ordinary manner to obtain the crude product, which was purified according to the silica gel column chromatography to obtain the title compound.

Provenance & Evidence