Trimethylsilyl isocyanate → HCID 58513601, compound

HRID 241658Notes

Reaction equation

HRID 241658 reaction equation
[CH:1]1([CH2:4][N:5]2[C:9]3[CH:10]=[CH:11][C:12]([S:14]([C@@H:17]4[CH2:21][CH2:20][NH:19][CH2:18]4)(=[O:16])=[O:15])=[CH:13][C:8]=3[N:7]=[C:6]2[CH2:22][C:23]([CH3:26])([CH3:25])[CH3:24])[CH2:3][CH2:2]1.C[Si]([N:31]=[C:32]=[O:33])(C)C>>[CH:1]1([CH2:4][N:5]2[C:9]3[CH:10]=[CH:11][C:12]([S:14]([C@@H:17]4[CH2:21][CH2:20][N:19]([C:32]([NH2:31])=[O:33])[CH2:18]4)(=[O:16])=[O:15])=[CH:13][C:8]=3[N:7]=[C:6]2[CH2:22][C:23]([CH3:26])([CH3:25])[CH3:24])[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 70696Trimethylsilyl isocyanateHCID 58513607HCID 58513607, compound

Product 1

HCID 58513601HCID 58513601, compound

Procedure

The title compound was prepared according to the procedure described in STEP D of Example 6 using 1-(cyclopropylmethyl)-2-(2,2-dimethylpropyl)-5-[(3R)-pyrrolidine-3-sulfonyl]-1H-1,3-benzodiazole (STEP D) and trimethylsilyl isocyanate instead of methanesulfonyl chloride.

Sources & evidence

ORD record
ord-3e75a68d515445daa27c84d50d5e21d1
Source dataset
uspto-grants-2014_02
Patent number
US08653063B2

Reaction notes

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