Triethylamine → Ethyl 1-(pyridin-4-yl)piperidine-4-carboxylate

Participants

Reaction Steps

4.0 g (26.6 mmol) of 4-chloropyridine hydrochloride, 4.2 g (26.6 mmol) of ethyl piperidine-4-carboxylate and 7.4 ml (53.2 mmol) of triethylamine were stirred in 100 ml of xylene at 130° C. for 24 hours. The reaction mixture was treated with ethyl acetate as the extraction solvent in an ordinary manner to obtain the title compound.

Provenance & Evidence