HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2416581Generated: October 31, 2026
Hydrochloric Acid → 1-(Pyridin-4-yl)piperidine-4-carboxylic acid hydrochloride
https://huagongshe.com/reaction/2416581
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl 1-(pyridin-4-yl)piperidine-4-carboxylate | HCID 9899468 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-(Pyridin-4-yl)piperidine-4-carboxylic acid hydrochloride | HCID 16217269 | — |
Reaction Steps
2.95 g (12.6 mmol) of ethyl 1-(4-pyridyl)-piperidine-4-carboxylate was stirred in 100 ml of dioxane. After adding 50 ml of 1 N hydrochloric acid, the obtained mixture was stirred at 95° C. for 20 hours. The solvent was evaporated under reduced pressure to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06825181B1 |
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| Source dataset | uspto-grants-2004_11 |
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| ORD ID | ord-89f584eae0ea4845b0c618e02e3dfa34 |
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| Source note | uspto-grants-2004_11 |
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