Dichloromethane → HCID 86759565, compound

Participants

Reaction Conditions

Reaction Steps

8.81 g (27 mmol) of 1-amino-7-hydroxyisoquinoline monohydrobromide was dissolved in 120 ml of DMF. 14.0 g (41 mmol) of benzyl (4R)-4-t-butoxycarbonylamino-5-chloropentanoate, 11.2 g (81.0 mmol) of potassium carbonate and 9.96 g (27 mmol) of tetrabutylammonium iodide were added to the obtained solution, and they were stirred at 70° C. for 3 days. After the treatment with dichloromethane as the extraction solvent in an ordinary manner, the obtained crude product was purified by the silica gel column chromatography to obtain the title compound.

Provenance & Evidence