Citric Acid → HCID 46852365, compound

Participants

Reaction Steps

To a solution of citric acid (200 mg, 1.04 mmol) in methanol (3 mL) was added N,N-dimethyl-2-(5-(1-(methylsulfonyl)azetidin-3-ylsulfonyl)-2-neopentyl-1H-benzo[d]imidazol-1-yl)ethanamine (STEP A, 476 mg, 1.04 mmol) and the mixture was concentrated in vacuo. To the residual amorphous was added ethanol (10 mL) and methanol at 60° C. until the solid was dissolved. The solution was cooled to room temperature and the precipitate was filtered. The white solid was dried under reduced pressure to give the title compound (525 mg, 78%).

Provenance & Evidence