Sodium hydride → HCID 22478542, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-[5-(3-methyl-3-hydroxy-butyn-1-yl)-3-pyridyl]-4-tert-butoxycarbonyl-homopiperazine (0.40 g, 1.1 mmol), sodium hydride 60% (4.5 mg, 0.11 mmol) and toluene (10 ml) was stirred at 110° C. for 3 h. The crude mixture was purified by chromatography on silica gel with ethyl acetate:toluene, (3:1) gave the title compound. Yield 0.13 g, 39%.

Provenance & Evidence