HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 10104631, compound → Ammonia
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 10104631 | HCID 10104631 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ammonia | HCID 222 | — |
| Product | 1-(pyridazin-3-yl)-1,4-diazepane | HCID 22053479 | — |
Reaction Steps
A mixture of 1-(3-Chloro-6-pyridazinyl)-homopiperazine (5.56 g, 26.1 mmol), palladium on carbon (2.1 g, 10%) and ethanol (150 ml) was stirred under hydrogen overnight. The crude product was filtered through celite and evaporated. Chromatography on silica gel with dichloromethane, methanol and conc. ammonia (89:10:1) gave the title compound as free base. Yield 2.78 g, 60%, 185.0-186.9° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06825189B1 |
| Source dataset | uspto-grants-2004_11 |
| ORD ID | ord-bc396a0d75ab4e1080bd8990b332a58c |
| Source note | uspto-grants-2004_11 |