Methyl Ethyl Ketone → Ethanol heptane

HRID 2416623Notes

Reaction equation

HRID 2416623 reaction equation
Cl.N([C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)C=NN=1)N.[CH3:14][C:15](=[O:18])CC>CO.O>[CH2:15]([OH:18])[CH3:14].[CH3:4][CH2:13][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

Participants

4

Reactant 2

HCID 6569Methyl Ethyl KetoneHCID 9351Hydralazine Hydrochloride

Product 1

HCID 22502148Ethanol heptaneYield 78%

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

A 10 parts 1-hydrazinophthalazine HCL (0.05 Molar) in 50% methanol-water are mixed with 1 part 2-butanone. After evaporation of solvents, 1-hydrazinophthalazine 2-butanone hydrazone is crystallized from ethanol-heptane (78% yield). [The Journal of Pharmacology and Experimental Therapeutics 205 (2): 418-425 (1978)].

Workup

  1. customAfter evaporation of solvents, 1-hydrazinophthalazine 2-butanone hydrazone

Sources & evidence

ORD record
ord-77e8b68bf263403d897db1294018b181
Source dataset
uspto-grants-2004_11
Patent number
US06825196B2

Reaction notes

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