Hydrochloric Acid → HCID 46852209, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (4-((1-(2-(dimethylamino)ethyl)-2-neopentyl-1H-benzo[d]imidazol-5-ylsulfonyl)methyl)piperidin-1-yl)(1H-pyrazol-4-yl)methanone (STEP D, 450 mg, 0.874 mmol) in ethanol (2 mL) was added 4 mol/L hydrogen chloride in ethyl acetate solution (215 microL, 0.869 mmol). To the resulting suspension was added methanol (2 mL) and the whole was heated at 85° C. for 20 min. The resulting suspension was cooled to 0° C. The white solid was isolated with filtration, to give the title compound (182 mg, 38%) as a white solid.

Provenance & Evidence