Hydroxylamine → HCID 22633101, compound

Participants

Reaction Steps

Scheme I-16-2 depicts the preparation of a 3-methyl-4-azabenzisoxazole ti derivative which may be used as starting material for Scheme I-16. Steps a, b, AP and c of equation 1 may be carried out as previously described for Scheme I-14-2. The acetyl derivative may then be treated with hydroxylamine to provide the oxime as depicted in step d and then cyclized as depicted in step e (as described for steps f and g of Scheme I-14, respectively) to provide the 3-methyl-4-azabenzisoxazole shown. In equation 2 of Scheme I-16-2 the 3-hydroxy-4-methoxypyridine is first acetylated (step a) then is treated with hydroxylamine and cyclized as previously described to provide 3-methyl-7-methoxy-4-azabenzisoxazole.

Provenance & Evidence