Chlorotrimethylsilane → HCID 58513609, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (S)-tert-butyl 3-(1-(2-(dimethylamino)ethyl)-2-neopentyl-1H-benzo[d]imidazol-5-ylsulfonyl)pyrrolidine-1-carboxylate (STEP E, 980 mg, 1.99 mmol) in methanol (6 mL) was added chlorotrimethylsilane (1.27 mL, 9.95 mmol). The mixture was stirred at 50° C. for 16 h. The resulting mixture was concentrated. The residue was added 2 mol/L sodium hydroxide aqueous solution to pH>7 and the mixture was extracted with ethyl acetate (150 mL). The organic layer was washed with brine and dried over sodium sulfate. The resulting solution was concentrated to give the title compound (776 mg, 99%) as an oil.

Provenance & Evidence