Pyridine → HCID 22633082, compound

Participants

Reaction Steps

The crude residue containing (1H-Indazol-3-yl)-2-oxo-acetyl chloride (50 mg) was dissolved in dry CH3CN (7 mL), and to the resulting solution was added 3-(R)-methyl-1-benzoyl piperazine (50 mg) and pyridine (1 mL). The reaction mixture was stirred for 1 hour at room temperature then was concentrated in vacuo. The resulting residue was purified using Shimadzu automated preparative HPLC System to give 1-(benzoyl)-4-[(1H-indazol-3-yl)-2-oxoacetyl]piperazine (2.5 mg). 1H NMR (500 MHz, MeOD) δ 8.42 (m, 2H), 7.90 (m, 1H), 7.69 (m, 1H), 7.46 (m, 5H), 5.00-3.00 (m, 8H), 1.30 (m, 3H). MS m/z: (M+H)+ calcd for C21H21N4O3:377.16; found 377.28. HPLC retention time: 1.49 minutes (column A).

Provenance & Evidence