Water → HCID 12136657, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 1-{4-[5-(4-chloro-benzenesulfonyl)2-methoxyphenyl]piperidin-1-yl}-2,2,2-trifluoro-ethanone (31) (77 mg) in methanol (2 mL), a solution of 6N NaOH (0.5 mL) was added. After stirring at 80° C. for 10 min, water was added (10 ml) and the mixture was extracted into ethyl acetate (20 ml). The organic phase was dried (Na2SO4) and concentrated in vacuo to give 4-[5-(4-chloro-benzenesulfonyl)2methoxy-phenyl] piperidine (301) as a white solid (0.054 g ), MS, MH+ 365. The hydrochloride salt was prepared from ethanol-hydrogen chloride, m.p. 235.5-236.0° C.

Provenance & Evidence