Dimethylformamide → HCID 10177273, compound

Participants

Reaction Conditions

Reaction Steps

A degassed mix of 3-bromo-7-cyano-5-trifluoromethyl-5-isopropoxymethyl-5,10-dihydrobenzo[b][1,8]naphthyridine (15) (73 mg, 0.171 mmol), Zn(CN)2 (20 mg, 0.171 mmol) and Pd(PPh3)4 (10 mg, 0.00855 mmol) in anhydrous DMF (2 mL) was heated at 100° C. for 16 h 30 min. The reaction mixture was cooled to room temperature, quenched 2 N NH4OH (20 mL), and extracted with EtOAc (2×). The combined organic layers were washed with brine, dried over MgSO4, filtered and concentrated in vacuo. Flash chromatography (20%-30% EtOAc-Hexane) provided 17 (38 mg, 60% yield) as a white solid: m.p. 226-227° C.; low resolution mass spectrum (ESI) m/z 371.2 [(M−H)— calcd for C19H14F3N4O: 371.11].

Provenance & Evidence