Acetic Acid → HCID 178493295, compound

Participants

Reaction Steps

A solution of 2-[(3-hydroxy-1-propyl)amino]-4-nitropyridine-N-oxide (0.275 g, 1 mmol) and 0.5 M NaOMe in MeOH (16 mL, 8 mmol) was heated at reflux under argon for 3 hr. The reaction was then allowed to cool, and glacial AcOH (0.5 mL, 8 mmol) was added. The solution was concentrated to dryness and the residue was triturated with CH2Cl2. The insoluble materials were removed by filtration and the filtrate was concentrated. Silica gel chromatography (5-15% MeOH/CH2Cl2) gave the title compound (0.23 g, 90%) as a colorless oil: MS (ES) m/e 199.0 (M+H)+.

Provenance & Evidence