Trifluoroacetic acid → HCID 10643299, compound

Participants

Reaction Steps

TFA (55 mL) was added all at once to a solution of methyl (±)-3-carbomethoxy-4-[2-[N-(tert-butoxycarbonyl)-N-(2,2,2-trifluoroethyl)amino]methyl-4-methoxyphenyl]butanoate (7.98 g, 16.71 mmole) in anhydrous CH2Cl2 (42 mL) at 0° C. under argon, and the reaction was warmed to RT. After 1.5 hr, the reaction was concentrated, and the residue was reconcentrated from xylenes. Drying in high vacuum at 40° C. left the title compound (8.70 g, quantitative) as a yellow solid: MS (ES) m/e 378 (M+H)+.

Provenance & Evidence